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New research on the placebo effect
By traveling the cavernous folds of the brain, researchers have found not only the pathways of pain, but ways it can be controlled without standard medications

By Dr. Sanjay Gupta, CNN

Dr. Tor Wager of the University of Michigan said, "We have more control over our own minds than we think we have."

The pain region of your brain is just behind your eyes -- the anterior cingulate cortex.

Dr. Matthew Lieberman of the University of California - Los Angeles said, "It kind of serves as an alarm system that tells the rest of the mind that you need to pay attention to this painful thing that's occurring."

Researchers said that alarm system is less active when drugs called placebos are given to patients. Before, scientists considered the placebo effect something patients made up.

Wager said, "We think that the placebo effect is real, so it really changes your experience of pain. That's something that we haven't really known before."

Brain scans were performed on patients with irritable bowel syndrome who thought they were receiving pain relief, but really received a placebo. Even with no medication, the area of the brain that controls how they perceive pain was less active.

Lieberman said, "This suggests there really is a physical basis in the brain, there's a pathway by which these thoughts and expectations about pain relief can actually lead to pain relief."

Another study from the University of Michigan suggests that merely believing in or expecting pain relief actually makes pain less intense. In that study, people who got a placebo had 25 percent less pain activity in their brain. They also reported 25 percent less pain.

Wager said, "When you're expecting pain with placebo, you might feel safer, you feel less anxious. Something in your brain is saying, 'I think this placebo is gonna work. I'm gonna be OK.'"

Research is ongoing, but scientists said one day our own minds could control pain as well as medications can.

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